Blockade of Motor Cortical Long-Term Potentiation Induction by Glutamatergic Dysfunction Causes Abnormal Neurobehavior in an Experimental Subarachnoid Hemorrhage Model
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چکیده
منابع مشابه
P19: Long-Term Potentiation
The term synaptic plasticity points to a series of persistent changes related to the activity of synapses. Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulations. Differe...
متن کاملP18: Signaling Pathway in Long-Term Potentiation
Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...
متن کاملLong-term potentiation of glutamatergic pathways in the lamprey brainstem.
Plasticity of synaptic transmission has been investigated in the lamprey brainstem. In this preparation, neurons of the vestibular nuclei make monosynaptic connections to reticulospinal neurons of the posterior (PRRN) and middle (MRRN) rhombencephalic reticular nuclei. This glutamatergic projection shows a long-lasting enhancement in efficacy following a brief high frequency (50 Hz) train of st...
متن کاملSelective intraarterial nimodipine treatment in an experimental subarachnoid hemorrhage model.
BACKGROUND AND PURPOSE Cerebral vasospasm secondary to subarachnoid hemorrhage (SAH) has been a serious clinical problem. The aim of the present study is to evaluate the efficacy of selective intraarterial (IA) nimodipine treatment in a rabbit model of chronic cerebral vasospasm. METHODS Twenty-two adult New-Zealand rabbits of either sex, weighing 2500-3800 g were used for this study. Followi...
متن کاملStochastic Induction of Long-Term Potentiation and Long-Term Depression
Long-term depression (LTD) and long-term potentiation (LTP) of granule-Purkinje cell synapses are persistent synaptic alterations induced by high and low rises of the intracellular calcium ion concentration ([Ca(2+)]), respectively. The occurrence of LTD involves the activation of a positive feedback loop formed by protein kinase C, phospholipase A2, and the extracellular signal-regulated prote...
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ژورنال
عنوان ژورنال: Frontiers in Neural Circuits
سال: 2021
ISSN: 1662-5110
DOI: 10.3389/fncir.2021.670189